Evaluating interleukin-16 expression in patients with grade-3 and grade-4 glial cell tumors and healthy individuals.

Abstract

Background:

This study evaluated the change in IL-16 levels in patients with high-grade glial tumors undergoing radiotherapy (RT) and healthy individuals (control group).

Materials and Methods:

Serum IL-16 levels of 35 high-grade glioma patients receiving radiotherapy (RT) and 30 healthy individuals were compared. We compared the IL-16 levels before (RT0) and after the (RT1) and IL-16 levels were measured and the relationship of this change with other characteristics such as age, gender, weight, height, and blood test results.

Results:

The RT0-IL-16 level was approximately 15 pg/ml higher than the RT1 measurement in the patient group. The mean RT0-IL-16 levels in the patient group were approximately 10 pg/ml higher than the mean IL-16 levels in the control group. Likewise, at the RT1 time-point, the mean IL-16 levels for the patient group were approximately 5 pg/ml lower than the mean IL-16 for the control group. The mean RT0-RT1-IL-16 value tended to be higher in female patients than in male patients.

Conclusion:

The application of RT reduces the overall IL-16 levels, suggesting the efficacy of RT, as well as the role of IL-16 in tumorigenesis.

• Authors: F Karaca, S Keskin, S Menteş, Z Boğa, G Çavuş, F Köksal
• Journal: Nigerian journal of clinical practice (Niger J Clin Pract) Vol. 26 Issue 10 Pg. 1456-1462 (Oct 2023) ISSN: 1119-3077 [Print] India
• PMID: 37929521 (Publication Type: Journal Article)

Chemical References

• Interleukin-16

Topics

• Humans
• Male
• Female
• Interleukin-16
• Glioma