Neurological and metabolic related pathophysiologies and treatment of comorbid diabetes with depression.
Abstract | BACKGROUND: AIMS: Given these problems, many researchers made remarkable efforts to analyze diabetes complicating depression from different aspects, including insulin resistance, stress and Hypothalamic-Pituitary-Adrenal axis, neurological system, oxidative stress, and inflammation. Drug therapy, such as Hydrogen Sulfide, Cannabidiol, Ascorbic Acid and Hesperidin, are conducive to alleviating diabetes mellitus and depression. Here, we reviewed the exact pathophysiology underlying the comorbidity between depressive disorder and diabetes mellitus and drug therapy. METHODS: The review refers to the available literature in PubMed and Web of Science, searching critical terms related to diabetes mellitus, depression and drug therapy. RESULTS: CONCLUSIONS: The review summarizes the mechanisms underlying the comorbidity. It also overviews drug therapy with anti-diabetic and anti-depressant effects.
|
Authors | Sixin Li, Dong Yang, Xuhui Zhou, Lu Chen, Lini Liu, Ruoheng Lin, Xinyu Li, Ying Liu, Huiwen Qiu, Hui Cao, Jian Liu, Quan Cheng |
Journal | CNS neuroscience & therapeutics
(CNS Neurosci Ther)
Vol. 30
Issue 4
Pg. e14497
(04 2024)
ISSN: 1755-5949 [Electronic] England |
PMID | 37927197
(Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
|
Copyright | © 2023 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd. |
Topics |
- Humans
- Animals
- Depression
(drug therapy, epidemiology)
- Insulin Resistance
- Hypothalamo-Hypophyseal System
- Pituitary-Adrenal System
- Diabetes Mellitus
(drug therapy, epidemiology)
- Comorbidity
- Diabetes Mellitus, Type 2
(drug therapy)
|
|
Join CureHunter, for free Research Interface BASIC access!
Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease.
Find out why thousands of doctors, pharma researchers and patient activists
around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!
|