Comprehensive genomic profiling testing in Japanese castration-resistant prostate cancer patients: results of a single-center retrospective cohort study.

Abstract

OBJECTIVE:

Comprehensive genomic profiling testing using a hybrid-capture next-generation sequencing is commonly used in clinical practice to employ precision medicine in cancer treatment worldwide. In this study, we aimed to analyze the profiles obtained using comprehensive genomic profiling testing that was performed in Japanese castration-resistant prostate cancer patients and to discuss the genetic findings in a real-world setting.

METHODS:

A total of 60 cases and 57 castration-resistant prostate cancer patients underwent comprehensive genomic profiling testing between 1 January 2021 and 31 December 2022. Four types of comprehensive genomic profiling testing were selected, and clinically significant cancer-specific gene alterations were identified.

RESULTS:

The median age of patients was 74 years, and the median prostate-specific antigen value at the time of submission was 18.6 ng/ml. Fifty-seven (95%) of 60 cases were metastatic castration-resistant prostate cancers, and 3 cases (5%) were non-metastatic. Among all genetic alterations, androgen-receptor alteration was the most frequently detected in 17 cases (28.3%), followed by 15 cases of TP53 (25.0%), 14 cases of CDK12 (23.3%), 10 cases of phosphatase and tensin homolog (16.7%) and 9 cases of ATM (15.0%) mutations. A total of 13 patients (21.7%) received systemic therapy according to the comprehensive genomic profiling testing results. Overall, the survival rate was significantly greater in the group treated through systemic therapy based on comprehensive genomic profiling testing compared with the group without new therapeutic treatment (P = 0.041).

CONCLUSIONS:

Comprehensive genomic profiling testing is recommended in castration-resistant prostate cancer patients identified as resistant to standard therapy as this can provide a new therapeutic option.

• Authors: Takafumi Fukushima, Keisuke Goto, Tetsutaro Hayashi, Kenichiro Ikeda, Tomoya Hatayama, Ryoken Yamanaka, Kyosuke Iwane, Ryo Tasaka, Yuki Kohada, Kenshiro Takemoto, Kohei Kobatake, Akihiro Goriki, Asuka Toshida, Hikaru Nakahara, Masanori Motonaga, Kentaro Tokumo, Yasutoshi Fujii, C Nelson Hayes, Wataru Okamoto, Toshio Kubo, Takashi Matsumoto, Masaki Shiota, Noboru Yamamoto, Yuji Urabe, Eiso Hiyama, Koji Arihiro, Takao Hinoi, Nobuyuki Hinata
• Journal: Japanese journal of clinical oncology (Jpn J Clin Oncol) Vol. 54 Issue 2 Pg. 175-181 (Feb 07 2024) ISSN: 1465-3621 [Electronic] England
• PMID: 37899139 (Publication Type: Journal Article)
• Copyright: © The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: [email protected].

Chemical References

• Prostate-Specific Antigen

Topics

• Male
• Humans
• Aged
• Prostatic Neoplasms, Castration-Resistant (drug therapy)
• Retrospective Studies
• Japan
• Prostate-Specific Antigen
• Genomics