Human adenovirus type 7 (HAdV7)
infection causes severe
pneumonia, yet there are still no breakthroughs in treatment options for adenovirus, and the road to
antiviral drug development faces major challenges. We attempted to find new drugs and we stumbled upon one: selenadiazole. Selenadiazole has been shown to have significant anti-
tumor effects due to its unique chemical structure and
drug activity. However, its effectiveness against viruses has not been evaluated yet. In our study, selenadiazole also showed superior
antiviral activity. In vitro experiments, selenadiazole was able to inhibit adenovirus-mediated mitochondrial-oxidative-damage-related apoptosis, and in in vivo experiments, selenadiazole was able to inhibit apoptosis by modulating the apoptotic signaling pathway Bcl-2/Stat3/NF-κB, etc., and was able to largely attenuate
adenovirus-infection-induced
pneumonia and
lung injury in mice. This study aims to describe a new
antiviral treatment option from the perspective of anti-adenovirus-mediated oxidative stress and its associated apoptosis and to provide theoretical guidance for the treatment of clinical
adenovirus infection to a certain extent.