Central adrenergic mechanisms in hemorrhage-induced vasopressin secretion.

Abstract

The effect of central administration of specific adrenergic agonists and antagonists on hemorrhage-induced vasopressin secretion was studied in conscious rats. The intracerebroventricular (icv) injection of the alpha 2-antagonist yohimbine, the alpha 1-antagonist corynanthine, or the beta-agonist isoproterenol failed to alter the vasopressin or blood pressure responses to two sequential 10% reductions in blood volume. Administration of the beta-antagonist propranolol, however, resulted in a significant attenuation of the vasopressin response to hemorrhage, with little effect on the blood pressure response. The alpha 2-agonist, butylated hydroxytoluene (BHT) 933, caused an enhanced vasopressin response to hemorrhage, with a resulting improved maintenance in blood pressure. The results indicate that both alpha 2- and beta-adrenoreceptors may be involved in the pressure-volume control of vasopressin secretion.

• Authors: D P Brooks, L Share, J T Crofton
• Journal: The American journal of physiology (Am J Physiol) Vol. 251 Issue 6 Pt 2 Pg. H1158-62 (Dec 1986) ISSN: 0002-9513 [Print] United States
• PMID: 3789169 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Arginine Vasopressin
• Butylated Hydroxytoluene
• Yohimbine
• Propranolol
• Isoproterenol

Topics

• Animals
• Arginine Vasopressin (metabolism)
• Blood Pressure (drug effects)
• Butylated Hydroxytoluene (pharmacology)
• Hemorrhage (physiopathology)
• Isoproterenol (pharmacology)
• Kinetics
• Male
• Propranolol (pharmacology)
• Rats
• Rats, Inbred Strains
• Yohimbine (pharmacology)