Abstract | BACKGROUND: METHODS: BRCA1/2-mutated patients with secondary platinum-sensitive relapse included in this study did not receive any maintenance regimen after first- and second-line platinum-based chemotherapy, and the secondary platinum-free interval (PFI) was more than 6 months. Patients in study group were treated with PARPi monotherapy until disease progression, and patients in control group were treated with platinum-based chemotherapy without restriction. Progression-free survival (PFS) was defined as the time from third-line therapy to disease progression or death, PFS2 was defined as the time from platinum-based chemotherapy after PARPi resistance to next subsequent therapy or death. Post-recurrence survival (PRS) refers to the survival time after secondary platinum-sensitive relapse. RESULTS: A total of 119 patients were retrospectively analyzed, including 71 (59.7%) in study group and 48 (40.3%) in control group. The objective response rate (ORR: 77.5% vs. 80.0%, p=0.766) and PFS (median: 11.2 vs. 11.0 months, p=0.962) were comparable. The benefit of subsequent platinum-based chemotherapy after PARPi resistance was more pronounced in patients with PARPi treatment for more than 12 months (median PFS2: 8.6 vs. 4.3 months, p=0.040). PARPi monotherapy had no adverse effect on PRS compared with platinum-based chemotherapy (median PRS:41.2 vs. 42.8 months, p=0.323). Compared to patients in control group who had never received PARPi, PARPi monotherapy (median PRS: 41.2 vs. 33.7 months, p=0.019) and post-line treatment with PARPi in the control group (median PRS: 48.1 vs. 33.7 months, p=0.002) could prolong PRS for patients with secondary platinum-sensitive relapse. CONCLUSIONS:
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Authors | Yana Ma, Jiale Liu, Ning Li, Hualei Bu, Yongwen Huang, Chengjuan Jin, Hao Wen, Shuai Feng, Hui Zhang, Xiaorong Yang, Beihua Kong, Lingying Wu, Kun Song |
Journal | Journal of ovarian research
(J Ovarian Res)
Vol. 16
Issue 1
Pg. 209
(Oct 28 2023)
ISSN: 1757-2215 [Electronic] England |
PMID | 37891662
(Publication Type: Journal Article)
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Copyright | © 2023. The Author(s). |
Chemical References |
- Poly(ADP-ribose) Polymerase Inhibitors
- BRCA1 protein, human
- BRCA1 Protein
- Ribose
- Platinum
- BRCA2 protein, human
- BRCA2 Protein
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Topics |
- Humans
- Female
- Poly(ADP-ribose) Polymerase Inhibitors
(pharmacology, therapeutic use)
- BRCA1 Protein
(genetics)
- Ribose
(therapeutic use)
- Platinum
(pharmacology, therapeutic use)
- Retrospective Studies
- Breast Neoplasms
(drug therapy, genetics)
- BRCA2 Protein
(genetics)
- Ovarian Neoplasms
(drug therapy, genetics)
- Carcinoma, Ovarian Epithelial
(drug therapy)
- Recurrence
- Disease Progression
- Neoplasm Recurrence, Local
(drug therapy, genetics)
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