Imaging-guided
therapy holds great potential for enhancing therapeutic performance in a personalized way. However, it is still challenging to develop appropriate multifunctional materials to overcome the limitations of current all-in-one
theranostic agents. In this study, we developed a one-for-all
theranostic nanoplatform called Mn(II)-
hemoporfin MOFs, designed specifically for MRI-guided sonodynamic
tumor therapy. The formation of MOF structures not only improves imaging but also enhances
therapeutic effects through collective actions. Furthermore, by modifying
polyethylene glycol (PEG), Mn(II)-
hemoporfin-PEG was able to enhance permeability and retention effects, ensuring long circulation in the blood and accumulation in the
tumor. MRI enhancement provided by Mn(II)-
hemoporfin-PEG remained localized at the
tumor site, with Mn(II)-
hemoporfin-PEG demonstrating 88.6% efficacy in sonodynamic
therapy testing in vivo. Mn(II)-
hemoporfin-PEG exhibits excellent longitudinal relaxation, MRI effects, and sonodynamic performance, making it a promising alternative for clinical
cancer treatment.