Abstract | BACKGROUND: METHODS: In this randomized, parallel-arm, double-blind, controlled clinical trial, we compared clinical resolution of experimental gingivitis by evaluating bleeding on probing, gingival index, and plaque index between stannous fluoride stabilized with zinc phosphate (test) and sodium fluoride (control) dentifrices. Further, these groups were compared for oral neutrophil counts, systemic priming of neutrophils, gingival crevicular fluid (GCF) expression of inflammatory markers, and the oral microbiome. RESULTS: We found significant reduction in bleeding on probing in the test group compared to the control group in experimental gingivitis when participants used the test dentifrice prior to induction of experimental gingivitis. The test group also showed significant reductions in GCF levels of inflammatory markers ( matrix metalloproteinase 8 [MMP8], receptor activator of nuclear factor kappa-Β ligand [RANKL]), oral polymorphonuclear neutrophil (PMN) counts, and systemic neutrophil priming (CD11b expression) during experimental gingivitis. Further, significant reductions in the gram-negative genera Porphyromonas, Tannerella, and Treponema were noted in the test group. CONCLUSION:
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Authors | Noah Fine, Abdelahhad Barbour, Kamini Kaura, Kristopher A Kerns, Dandan Chen, Harsh M Trivedi, Juliana Gomez, Amarpreet Sabharwal, Jeffrey S McLean, Richard P Darveau, Michael Glogauer |
Journal | Journal of periodontology
(J Periodontol)
Vol. 95
Issue 5
Pg. 421-431
(May 2024)
ISSN: 1943-3670 [Electronic] United States |
PMID | 37885337
(Publication Type: Journal Article, Randomized Controlled Trial, Comparative Study)
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Copyright | © 2023 The Authors. Journal of Periodontology published by Wiley Periodicals LLC on behalf of American Academy of Periodontology. |
Chemical References |
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Topics |
- Humans
- Gingivitis
(microbiology, prevention & control)
- Dentifrices
(therapeutic use)
- Double-Blind Method
- Tin Fluorides
(therapeutic use)
- Female
- Male
- Gingival Crevicular Fluid
- Adult
- Periodontal Index
- Neutrophils
(drug effects)
- Sodium Fluoride
(therapeutic use)
- Young Adult
- Dental Plaque Index
- RANK Ligand
- Matrix Metalloproteinase 8
(analysis)
- Phosphates
(therapeutic use)
- Microbiota
(drug effects)
- Zinc Compounds
(therapeutic use)
- Leukocyte Count
- Treatment Outcome
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