Abstract | Background: Aims: This study explored the causal relationship between gut microbiota and cholelithiasis. We hypothesize that the gut microbiota influences cholelithiasis development. Methods: A two-sample Mendelian randomization method was combined with STRING analysis to test this hypothesis. Summary data on gut microbiota and cholelithiasis were obtained from the MiBioGen (n=13,266) and FinnGen R8 consortia (n=334,367), respectively. Results: Clostridium senegalense, Coprococcus3, and Lentisphaerae increased the risk of cholelithiasis and expressed more bile salt hydrolases. In contrast, Holdemania, Lachnospiraceae UCG010, and Ruminococcaceae NK4A214 weakly expressed bile salt hydrolases and were implied to have a protective effect against cholelithiasis by Mendelian randomization analysis. Conclusion:
|
Authors | Xin Liu, Xingsi Qi, Rongshuang Han, Tao Mao, Zibin Tian |
Journal | Frontiers in cellular and infection microbiology
(Front Cell Infect Microbiol)
Vol. 13
Pg. 1253447
( 2023)
ISSN: 2235-2988 [Electronic] Switzerland |
PMID | 37876873
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2023 Liu, Qi, Han, Mao and Tian. |
Chemical References |
|
Topics |
- Humans
- Gastrointestinal Microbiome
(genetics)
- Mendelian Randomization Analysis
- Cardiovascular Diseases
- Clostridiales
- Bile Acids and Salts
- Genome-Wide Association Study
|