A pilot randomized clinical trial of γ-tocopherol supplementation on wood smoke-induced neutrophilic and eosinophilic airway inflammation.

Abstract

Background:

Air pollutants, including particulates from wood smoke, are a significant cause of exacerbation of lung disease. γ-Tocopherol is an anti-inflammatory isoform of vitamin E that has been shown to reduce allergen-, ozone-, and endotoxin-induced inflammation.

Objective:

The objective of this study was to determine whether γ-tocopherol would prevent experimental wood smoke-induced airway inflammation in humans.

Methods:

This was a randomized, placebo-controlled clinical trial testing the effect of a short course of γ-tocopherol-enriched supplementation on airway inflammation following a controlled exposure to wood smoke particulates.

Results:

Short-course γ-tocopherol intervention did not reduce wood smoke-induced neutrophilic airway inflammation, but it did prevent wood smoke-induced eosinophilic airway inflammation.

Conclusion:

γ-Tocopherol is a potential intervention for exacerbation of allergic airway inflammation, but further study examining longer dosing periods is required.

• Authors: David B Peden, Martha Almond, Christian Brooks, Carole Robinette, Heather Wells, Allison Burbank, Michelle Hernandez, Alan Hinderliter, Melissa Caughey, Qing Jiang, Qianyue Wang, Haolin Li, Haibo Zhou, Neil Alexis
• Journal: The journal of allergy and clinical immunology. Global (J Allergy Clin Immunol Glob) Vol. 2 Issue 4 Pg. 100177 (Nov 2023) ISSN: 2772-8293 [Electronic] United States
• PMID: 37876758 (Publication Type: Journal Article)
• Copyright: © 2023 The Author(s).