Abstract | BACKGROUND: METHODS: RESULTS:
Creatininase- peroxidase method was impacted by NAC interference in a clinically-significant manner at therapeutic NAC levels (basal value recovery of 80 % and 70 % for 500 and 1000 mg.L-1 of NAC, respectively), surpassing the desirable Reference Change Value (RCV%). Enzymo-amperometric methods were not impacted. Among patients, a mean bias of -45.2 ± 28.0 % was observed for the peroxidase detection method compared to the amperometric in those who received NAC prior plasma sampling and -2.7 ± 5.4 % in those who did not. CONCLUSIONS: Our findings indicate that enzymo-amperometric creatinine assays remain unaffected by NAC interference due to the absence of the peroxidase step in the analytical process. Therefore, these methods are suitable to prevent spurious hypocreatininemia in APAP intoxicated patients undergoing NAC therapy.
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Authors | Charles R Lefèvre, Felipe Le Divenah, Nicolas Collet, Romain Pelletier, Eric Robert, Martine Ropert, Maxime Pawlowski, Thomas Gicquel, Claude Bendavid |
Journal | Clinica chimica acta; international journal of clinical chemistry
(Clin Chim Acta)
Vol. 551
Pg. 117611
(Nov 01 2023)
ISSN: 1873-3492 [Electronic] Netherlands |
PMID | 37865270
(Publication Type: Journal Article)
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Copyright | Copyright © 2023 Elsevier B.V. All rights reserved. |
Chemical References |
- Acetylcysteine
- Acetaminophen
- Creatinine
- Peroxidase
- Peroxidases
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Topics |
- Humans
- Acetylcysteine
(therapeutic use)
- Acetaminophen
- Creatinine
- Retrospective Studies
- Peroxidase
- Peroxidases
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