Supplementation with Ashitaba (Angelica keiskei) Yellow Stem Exudate Prevents Aging-Induced Thrombotic Tendencies and Systemic Inflammation Without Affecting Body Weight Gain in Mice.

Abstract

Angelica keiskei Koidzumi (Ashitaba) is a traditional folk medicine and health supplement in Japan. Ashitaba yellow stem exudate (AYE) contains abundant chalcones and thus has the potential to treat and prevent many pathological states such as cancer, inflammation, obesity, diabetics, thrombosis, and hypertension. Levels of plasminogen activator inhibitor 1 (PAI-1), a key regulator of the fibrinolytic system, increase with age in mouse plasma. Therefore, we aimed to determine the effects of AYE on plasma thrombotic parameters in aging mice. Long-term (52 weeks) AYE supplementation significantly decreased age-induced increases of PAI-1 in mouse plasma. Supplementation with AYE decreased levels of the acute-phase and fibrinolytic protein plasma plasminogen, and significantly decreased those of tumor necrosis factor α. These results suggested that continuous intake of AYE throughout life decreases age-induced systemic inflammation and prevents thrombotic tendencies without affecting body weight gain in aged mice. Our findings showed that supplementing diets with AYE might help to prevent thrombotic diseases in elderly individuals.

• Authors: Naoki Ohkura, Riyo Morimoto-Kamata, Katsutaka Oishi, Sayaka Higo-Yamamoto, Aya Fujinami, Ken-Ichi Inoue, Mitsuhiro Ohta
• Journal: Journal of medicinal food (J Med Food) Vol. 26 Issue 11 Pg. 843-848 (Nov 2023) ISSN: 1557-7600 [Electronic] United States
• PMID: 37862040 (Publication Type: Journal Article)

Chemical References

• Plasminogen Activator Inhibitor 1

Topics

• Humans
• Animals
• Mice
• Aged
• Plasminogen Activator Inhibitor 1
• Angelica
• Weight Gain
• Inflammation (drug therapy)
• Thrombosis (drug therapy, prevention & control)
• Exudates and Transudates
• Dietary Supplements