[Clinical characteristics and prognostic factors of distant metastatic penile cancer].

Abstract

OBJECTIVE:

To investigate the clinical features of distant metastatic penile cancer (DMPC) and the factors influencing its prognosis.

METHODS:

We searched the Surveillance, Epidemiology and End Results Database for cases of DMPC diagnosed between 2004 and 2019, analyzed their clinical characteristics and the cancer-specific survival (CSS) rates relating to different factors using the Kaplan-Meier method and the differences among the variables by log-rank test. We determined the variables independently associated with CSS by Cox regression analysis.

RESULTS:

According to the inclusion criteria, 108 cases of DMPC were identified. The patients were mainly married White people, with a median CSS of 9 months, and 1-, 2- and 3-year CSS rates of 36.4%, 17.8% and 13.5%, respectively. Pairwise comparison showed no statistically significant differences in the median overall CSS among the patients in the surgery, chemotherapy and surgery + chemotherapy groups (8 mo vs 9 mo vs 13 mo, P > 0.05). Race was an independent factor affecting the prognosis of CSS.

CONCLUSION:

Distant metastatic penile cancer is a rare malignancy with poor prognosis, for which there have been no existing ideal treatment options.

• Authors: Chao-Peng Tang, Kai Zhou, Zheng-Cheng Sheng, Yu-Lin Zhou, Shui-Gen Zhou, Song Xu
• Journal: Zhonghua nan ke xue = National journal of andrology (Zhonghua Nan Ke Xue) Vol. 29 Issue 2 Pg. 151-157 (Feb 2023) ISSN: 1009-3591 [Print] China
• PMID: 37847087 (Publication Type: English Abstract, Journal Article)

Chemical References

• Dimyristoylphosphatidylcholine

Topics

• Male
• Humans
• Prognosis
• Neoplasm Staging
• Penile Neoplasms (therapy)
• Dimyristoylphosphatidylcholine