Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: Here we present currently available data on fertility, pregnancy, and parenthood in the modern era of cystic fibrosis care. Fertility may be improving in female individuals with cystic fibrosis with the use of CFTR modulator therapies, and there is an associated increase in annual pregnancies. Infertility in male individuals with cystic fibrosis remains approximately 97-98% and is unchanged with CFTR modulators in those already born with cystic fibrosis. As more female individuals with cystic fibrosis experience pregnancy, questions remain about the impact of pregnancy on their health and that of their child. Fortunately, there are multiple routes to becoming a parent; however, more work is needed to understand the impact of pregnancy and parenthood in the context of CF as some previous data suggests potential challenges to the health of parents with cystic fibrosis. SUMMARY: We encourage cystic fibrosis care teams to have knowledge and resources available to support the reproductive goals of all individuals with cystic fibrosis.
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Authors | Raksha Jain, Traci M Kazmerski, Jennifer L Taylor-Cousar |
Journal | Current opinion in pulmonary medicine
(Curr Opin Pulm Med)
Vol. 29
Issue 6
Pg. 595-602
(11 01 2023)
ISSN: 1531-6971 [Electronic] United States |
PMID | 37789771
(Publication Type: Review, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved. |
Chemical References |
- Cystic Fibrosis Transmembrane Conductance Regulator
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Topics |
- Child
- Pregnancy
- Male
- Humans
- Female
- Cystic Fibrosis
(therapy)
- Cystic Fibrosis Transmembrane Conductance Regulator
(genetics)
- Fertility
- Parents
- Mutation
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