Abstract | Background: Methods:
Tumor RNA expression and clinicopathologic data from a large cohort with TNBC (N=286) was used to identify RNA expression signatures of disease. Various drug-induced RNA expression profiles were extracted from multimodal RNA expression datasets and analyzed to estimate the RNA expression effects of ICI, opioids, and ketamine on TNBC. Results: We identified a RNA expression network in CD8+ T-cells that was relevant to TNBC pathogenesis and prognosis. Both opioids and anti-PD-L1 ICI regulated RNA expression in this network, suggesting a nexus for opioid-ICI interaction. Morphine and anti-PD-L1 therapy regulated RNA expression in opposing directions. By contrast, there was little overlap between the effect of ketamine and anti-PD-L1 therapy on RNA expression. Conclusions:
Opioids and ICI may target a common immune network in TNBC and regulate gene expression in opposing fashion. No available evidence supports a similar interaction between ketamine and ICI.
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Authors | Joseph R Scarpa, Giacomo Montagna, George Plitas, Amitabh Gulati, Gregory W Fischer, Joshua S Mincer |
Journal | Frontiers in oncology
(Front Oncol)
Vol. 13
Pg. 1267532
( 2023)
ISSN: 2234-943X [Print] Switzerland |
PMID | 37781176
(Publication Type: Journal Article)
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Copyright | Copyright © 2023 Scarpa, Montagna, Plitas, Gulati, Fischer and Mincer. |