Abstract | BACKGROUND: It is well documented that inappropriate use of antimicrobials is the major driver of antimicrobial resistance. To combat this, antibiotic stewardship has been demonstrated to reduce antibiotic usage, decrease the prevalence of resistance, lead to significant economic gains and better patients' outcomes. In Nigeria, antimicrobial guidelines for critically ill patients in intensive care units (ICUs), with infections are scarce. We set out to develop antimicrobial guidelines for this category of patients. METHODS: A committee of 12 experts, consisting of Clinical Microbiologists, Intensivists, Infectious Disease Physicians, Surgeons, and Anesthesiologists, collaborated to develop guidelines for managing infections in critically ill patients in Nigerian ICUs. The guidelines were based on evidence from published data and local prospective antibiograms from three ICUs in Lagos, Nigeria. The committee considered the availability of appropriate antimicrobial drugs in hospital formularies. Proposed recommendations were approved by consensus agreement among committee members. RESULTS: CONCLUSION: Data from a multicenter three ICU surveillance and antibiograms and publications from different hospitals in the country was used to produce this evidence-based Nigerian-specific antimicrobial treatment guidelines of critically ill patients in ICUs by a group of experts from different specialties in Nigeria. The implementation of this guideline will facilitate learning, continuous improvement of stewardship activities and provide a baseline for updating of guidelines to reflect evolving antibiotic needs.
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Authors | R O Oladele, A O Ettu, N Medugu, A Habib, E Egbagbe, T Osinaike, O B Makanjuola, B Ogunbosi, O O Irowa, J Ejembi, N S Uwaezuoke, G Adeleke, B Mutiu, F Ogunsola, V Rotimi |
Journal | West African journal of medicine
(West Afr J Med)
Vol. 40
Issue 9
Pg. 962-972
(Sep 28 2023)
ISSN: 0189-160X [Print] Nigeria |
PMID | 37768104
(Publication Type: Journal Article, Practice Guideline)
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Copyright | Copyright © 2023 by West African Journal of Medicine. |
Chemical References |
- Amikacin
- Anti-Bacterial Agents
- Anti-Infective Agents
- Ceftriaxone
- Clavulanic Acid
- Fluconazole
- Meropenem
- Piperacillin, Tazobactam Drug Combination
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Topics |
- Humans
- Amikacin
(therapeutic use)
- Anti-Bacterial Agents
(therapeutic use)
- Anti-Infective Agents
(therapeutic use)
- Ceftriaxone
(therapeutic use)
- Clavulanic Acid
(therapeutic use)
- Community-Acquired Infections
- Critical Illness
- Cross Infection
(drug therapy, microbiology)
- Fluconazole
(therapeutic use)
- Meropenem
(therapeutic use)
- Microbial Sensitivity Tests
- Nigeria
- Piperacillin, Tazobactam Drug Combination
(therapeutic use)
- Pneumonia
- Prospective Studies
- Urinary Tract Infections
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