Abstract | INTRODUCTION: AREAS COVERED: This review presents a comprehensive overview of targeted therapies and immunotherapies currently developed and evaluated in vitro and in vivo for NF1-altered cancer treatment. A PubMed database literature review was performed to select relevant original articles. Active clinical trials were researched in ClinicalTrials.gov database in August 2022. TCGA and HGMD® databases were consulted. EXPERT OPINION: This review highlights the need to better understand the molecular mechanisms of NF1-altered tumors and the development of innovative strategies to effectively target NF1-loss in human cancers. One of the current major challenges in cancer management is the targeting of tumor suppressor genes such as NF1 gene. Currently, most studies are focusing on inhibitors of the RAS/MAPK and PI3K-AKT-mTOR pathways and immunotherapies.
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Authors | Jean-Stéphane Giraud, Ivan Bièche, Éric Pasmant, Camille Tlemsani |
Journal | Expert opinion on investigational drugs
(Expert Opin Investig Drugs)
2023 Jul-Dec
Vol. 32
Issue 10
Pg. 941-957
ISSN: 1744-7658 [Electronic] England |
PMID | 37747491
(Publication Type: Journal Article, Review)
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Chemical References |
- Neurofibromin 1
- Proto-Oncogene Proteins c-akt
- Phosphatidylinositol 3-Kinases
- TOR Serine-Threonine Kinases
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Topics |
- Humans
- Neurofibromatosis 1
(genetics, metabolism, pathology)
- Neurofibromin 1
(genetics, metabolism)
- Genes, Neurofibromatosis 1
- Proto-Oncogene Proteins c-akt
- Precision Medicine
- Phosphatidylinositol 3-Kinases
(genetics)
- TOR Serine-Threonine Kinases
(metabolism)
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