Eosinophilic
duodenitis is an
inflammation of the duodenum, characterized by an abundance of eosinophils, typically triggered by
hypersensitivity reactions. Typically, recurrent
abdominal pain with eosinophilic
duodenitis is rare in individuals without a history of atopic conditions like
asthma. Here, we present the case of a 62-year-old man who experienced recurrent upper
abdominal pain for 12 months and unintended
weight loss for the past six months. The patient reported no
allergies to food, drugs, or the environment, and has no history of other atopic conditions. Esophagogastroduodenoscopy (EGD) with biopsy of the duodenum and stomach revealed 32 eosinophils per high-power field (HPF), which is mild. Skin prick testing yielded negative results. Following initial treatment with H2
inhibitors, proton pump inhibitors, and
budesonide for a total of 12 weeks, the patient reported an improvement in symptoms and subsequent
weight gain. This report emphasizes a rare case of eosinophilic
duodenitis in a nonatopic individual with a successful treatment regimen. His quality of life improved with
weight gain, resolved
abdominal pain, and improved appetite. Although the patient's condition lasted about 12 months, our report showcased the importance of timely clinical diagnosis and appropriate combination
therapy to alleviate progressive
pain associated with eosinophilic
duodenitis.