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Suppressing succinate accumulation during ischemia protects the kidney from IRI.

Abstract
Previous studies have indicated that succinate accumulation during kidney ischemia, and its oxidation during reperfusion, results in the production of excessive reactive oxygen species, mitochondrial dysfunction, and kidney injury. In this issue, Oh et al. have reported that pyruvate dehydrogenase kinase 4 (PDK4) inhibition in proximal tubules ameliorates kidney ischemia/reperfusion injury via suppressed succinate accumulation. This study suggests that PDK4 inhibition is a promising new treatment strategy for ischemic acute kidney injury.
AuthorsNobuaki Nishima, Shinji Tanaka
JournalKidney international (Kidney Int) Vol. 104 Issue 4 Pg. 646-649 (10 2023) ISSN: 1523-1755 [Electronic] United States
PMID37739613 (Publication Type: Journal Article, Comment)
CopyrightCopyright © 2023 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Succinic Acid
  • Succinates
Topics
  • Humans
  • Succinic Acid
  • Succinates
  • Kidney
  • Ischemia
  • Acute Kidney Injury (etiology, prevention & control)

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