Infections due to Salmonella sp. in children with chronic granulomatous disease: Our experience from North India.

Abstract

Infections with non-typhoidal Salmonella sp. have been documented in children with chronic granulomatous disease (CGD), but the prevalence of salmonella infection in children with CGD in underdeveloped countries is unknown. We assessed the clinical profiles of CGD patients diagnosed at our tertiary care centre in north India and had Salmonella sp.infections. We found three patients with Salmonella sp. bloodstream infections (2-proven, 1-probable) among the 99 CGD patients. After receiving cotrimoxazole prophylaxis following a CGD diagnosis, we noted that none of our patients experienced non-typhoidal salmonella infection. One patient experienced severe typhoidal bacteremia despite receipt of cotrimoxazole prophylaxis. This patient required numerous hospital admissions and prolonged intravenous antibiotic regimen. We suggest that vaccination with killed typhoidal vaccines should be regularly given to children with CGD in order to avoid typhoidal bacteremia, in addition to cotrimoxazole prophylaxis and a focus on good hand and food hygiene.

• Authors: Suprit Basu, Pandiarajan Vignesh, K Prithiviraj, Pallavi L Nadig, Aravind Sekar, Amit Rawat
• Journal: Clinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 255 Pg. 109769 (10 2023) ISSN: 1521-7035 [Electronic] United States
• PMID: 37704015 (Publication Type: Journal Article)
• Copyright: Copyright © 2023. Published by Elsevier Inc.

Chemical References

• Trimethoprim, Sulfamethoxazole Drug Combination

Topics

• Humans
• Child
• Trimethoprim, Sulfamethoxazole Drug Combination (therapeutic use)
• Granulomatous Disease, Chronic (complications, diagnosis)
• Salmonella
• Salmonella Infections (drug therapy, epidemiology)
• Typhoid Fever
• Bacteremia (drug therapy, epidemiology)