Polymeric micelles loaded in situ gel with prednisolone acetate for ocular inflammation: development and evaluation.

Abstract

Aim: Our study developed a prednisolone acetate polymeric micelles (PM) system for ocular inflammation related to allergic uveitis. Methods: For PM development, a thin-film hydration procedure was used. Irritation, in vitro, ex vivo transcorneal permeation, micelle size, entrapment efficiency and histology within the eye were all calculated for PM. Results: The optimized in situ gel (A4) showed superior ex vivo transcorneal permeation with zero-order kinetics. Conclusion: The developed formulation could be a promising candidate for treating anterior uveitis via topical application to the anterior segment of the eye.

• Authors: Nikita Kaushal, Manish Kumar, Abhishek Tiwari, Varsha Tiwari, Kamini Sharma, Ajay Sharma, Arya Lakshmi Marisetti, Madan Mohan Gupta, Imran Kazmi, Sami I Alzarea, Waleed Hassan Almalki, Gaurav Gupta
• Journal: Nanomedicine (London, England) (Nanomedicine (Lond)) Vol. 18 Issue 20 Pg. 1383-1398 (Aug 2023) ISSN: 1748-6963 [Electronic] England
• PMID: 37702303 (Publication Type: Journal Article)