Evolution of peptide YY analogs for the management of type 2 diabetes and obesity.

Abstract

Peptide YY (PYY) is a gastrointestinal hormone consisting of 36 amino acids, that is predominantly secreted by intestinal l-cells. Originally extracted from pig intestines, it belongs to the pancreatic polypeptide (PP) family, but has functions distinct from those of PP and neuropeptide Y (NPY). PYY is a potential treatment for type 2 diabetes mellitus (T2DM) because of its ability to delay gastric emptying, reduce appetite, decrease weight, and lower blood glucose. However, the clinical use of PYY is limited because it is rapidly cleared by the kidneys and degraded by enzymes. In recent years, researchers have conducted various structural modifications, including amino acid substitution, PEGylation, lipidation, and fusion of PYY with other proteins to prolong its half-life and enhance its biological activity. This study presents an overview of the recent progress on PYY, including its physiological functions, metabolites and structure-activity relationships.

• Authors: Wang Chen, Gong Binbin, Sun Lidan, Zhou Qiang, Han Jing
• Journal: Bioorganic chemistry (Bioorg Chem) Vol. 140 Pg. 106808 (11 2023) ISSN: 1090-2120 [Electronic] United States
• PMID: 37666110 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2023 Elsevier Inc. All rights reserved.

Chemical References

• Peptide YY
• Amino Acids

Topics

• Animals
• Swine
• Peptide YY
• Diabetes Mellitus, Type 2 (drug therapy)
• Obesity (drug therapy)
• Amino Acid Substitution
• Amino Acids