[A case of total hip arthroplasty for femoral head necrosis while using satralizumab for neuromyelitis optica spectrum disorders].

Abstract

A 47-year-old woman developed right femoral head necrosis during long-term steroid use for neuromyelitis optica spectrum disorder. She underwent a total hip arthroplasty because her right hip pain persisted after satralizumab treatment. There were no postoperative infections. Under oral administration of tacrolimus 3 mg, prednisolone 11 mg, and acetaminophen 2,275 mg, her postoperative body temperature was less than 38°C and normalized in about 2 days after the operation. No parameters indicating worsening of inflammation were observed in the blood test. In satralizumab-treated patients, infection cannot be ruled out even without inflammatory findings. In particular, if a slight fever of the 37°C-range or a mildly high white blood cell count persists, paying attention to signs of infection and actively investigating the presence or absence of infection using medical image diagnostic devices are necessary.

• Authors: Manabu Inoue, Shingo Maeda, Hirotsugu Ohashi
• Journal: Rinsho shinkeigaku = Clinical neurology (Rinsho Shinkeigaku) Vol. 63 Issue 9 Pg. 592-595 (Sep 20 2023) ISSN: 1882-0654 [Electronic] Japan
• PMID: 37648476 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• satralizumab

Topics

• Humans
• Female
• Middle Aged
• Neuromyelitis Optica (diagnosis, drug therapy)
• Arthroplasty, Replacement, Hip (adverse effects)
• Femur Head Necrosis (diagnostic imaging, etiology, surgery)
• Inflammation