Safety, feasibility, and quality of thulium laser en-bloc resection for treatment of non-muscle invasive bladder cancer.

Abstract

BACKGROUND:

Trans-Urethral Resection of Bladder Tumors (TURBT) is a critical step in diagnosis, staging and treatment of bladder tumors. Conventional TURBT (cTURBT) involves the electro-resection of the tumor into small fragments. This technique leads to concerns about the completeness of resection, under-staging, bleeding, cancer cell implantation, and most importantly, risk of tumour recurrence. To circumvent this, laser en-bloc resection of bladder tumors has been introduced.

OBJECTIVES:

Assessment of the safety, feasibility, and quality of Thulium Laser En-bloc Resection of Tumors (TmL-ERBT) for treatment of Non-Muscle Invasive Bladder Cancer (NMIBC) in various urinary bladder walls as a primary endpoint. The secondary endpoints were to investigate the feasibility of thulium laser use in the re-staging cystoscopy and to evaluate the learning curve of TmL-ERBT.

METHODS:

This is a prospective observational study including all newly diagnosed patients, above 18 years old, with a urinary bladder mass ≤ 4 cm in maximal dimension (measured via bladder ultrasound or CT or MRI). All patients underwent TmL-ERBT under regional anaesthesia in a lithotomy position. All intraoperative complications such as obturator nerve reflex, bladder perforation, and significant bleeding were recorded. Postoperative variables such as the mean catheterization time, bladder irrigation fluid volume and duration, and the mean of hospital stay as well as the postoperative complications were recorded. All patients were risk stratified and managed according to EUA guidelines then followed by a surveillance regimen per 3 months for 6 months.

RESULTS:

The study included 23 patients with a mean age of 53 ± 15.8 years. While 15 patients (65%) had a single tumor, the rest had multiple tumors, ranging from 2 to 3 in number with a total of 36 lesions. No cases required conversion to cTURBT and none of them experienced obturator nerve reflex or bladder perforation. Only one patient (4.3%) had an attack of clot urine retention. The mean hospitalization time was 31.2 ± 14.4 h and the mean catheterization time was 20.4 ± 13.3 h. The Detrusor muscle was present in 20 patients (87%) and the remaining 3 patients required a re-staging cystoscopy which was performed efficiently using thulium laser. None of the treated patients developed tumour recurrence during the follow-up period. In analysis, the duration of complete resection of 2-4 cm tumours was 23-27 min after the 7th case with a resection rate of 0.12-0.15 cm/min.

CONCLUSION:

TmL-ERBT is safe and feasible for complete resection of NMIBC with a short learning curve and adequate cancer control.

• Authors: Ahmed Assem, Ayman Kassem, Mohamed Sherif, Amr Lotfi, Mohamed Abdelwahed
• Journal: International urology and nephrology (Int Urol Nephrol) Vol. 55 Issue 12 Pg. 3103-3109 (Dec 2023) ISSN: 1573-2584 [Electronic] Netherlands
• PMID: 37639155 (Publication Type: Observational Study, Journal Article)
• Copyright: © 2023. The Author(s).

Chemical References

• Thulium

Topics

• Adult
• Aged
• Humans
• Middle Aged
• Cystectomy
• Feasibility Studies
• Lasers
• Neoplasm Recurrence, Local (pathology)
• Non-Muscle Invasive Bladder Neoplasms
• Thulium
• Urinary Bladder Neoplasms (surgery, pathology)