A Narrative Review of Flutamide in Juvenile Nasopharyngeal Angiofibroma.

Abstract

The detection of androgen receptors within Juvenile Nasopharyngeal Angiofibroma (JNA) has prompted investigation of the role of Flutamide. The aim of this review is to evaluate Flutamide as a possible neo-adjuvant treatment for JNA. Literature searches were conducted using MEDLINE, EMBASE and Web of Science. The Joanna Briggs Institute (JBI) checklist was used to assess risk of bias. The Oxford Centre of Evidence-Based Medicine (OCEBM) Levels of Evidence was used to stratify the evidence level. Literature searches were conducted using MEDLINE, EMBASE and Web of Science. Flutamide as neo-adjuvant treatment potentially causes a reduction in JNA tumor volume by ≥ 25%. Based on the current limited evidence, Flutamide has a limited role in JNA management and further research is required. Its utilization should only follow discussion with the patient, their families, and within the multidisciplinary team.

• Authors: Alison Emily Lim, Rhona Hurley, Mohd Afiq Mohd Slim, Louise Melia
• Journal: Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India (Indian J Otolaryngol Head Neck Surg) Vol. 75 Issue 3 Pg. 2707-2712 (Sep 2023) ISSN: 2231-3796 [Print] India
• PMID: 37636686 (Publication Type: Journal Article)
• Copyright: © Association of Otolaryngologists of India 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.