Ferroptosis regulation by methylation in cancer.

Abstract

Epigenetic regulation plays a critical role in cancer development and progression. Methylation is an important epigenetic modification that influences gene expression by adding a methyl group to nucleic acids and proteins. Ferroptosis is a new form of regulated cell death triggered by the accumulation of iron and lipid peroxidation. Emerging evidence have shown that methylation regulation plays a significant role in the regulation of ferroptosis in cancer. This review aims to explore the methylation regulation of ferroptosis in cancer, including reactive oxygen species and iron bio-logical activity, amino acid and lipid metabolism, and drugs interaction. The findings of this review may provide new insights and strategies for the prevention and treatment of cancer.

• Authors: Mengqiu Hao, Yixin Jiang, Yang Zhang, Xuyang Yang, Junhong Han
• Journal: Biochimica et biophysica acta. Reviews on cancer (Biochim Biophys Acta Rev Cancer) Vol. 1878 Issue 6 Pg. 188972 (11 2023) ISSN: 1879-2561 [Electronic] Netherlands
• PMID: 37634887 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2023. Published by Elsevier B.V.

Chemical References

• Iron

Topics

• Humans
• Cell Death (genetics)
• Epigenesis, Genetic
• Ferroptosis (genetics)
• Iron (metabolism)
• Neoplasms (genetics, therapy)
• Methylation