Abstract | BACKGROUND: METHODS: The expression of Bcl-2, survivin, P-glycoprotein/ABCB1, MRP1/ABCC1, and BCRP/ABCC2 was analyzed using immunohistochemistry in tumor specimens obtained from patients with DLBCL, and classified according to the treatment response as Remission, Relapsed, and (primary) Refractory groups. All patients received R-CHOP or equivalent treatment. RESULTS: Bcl-2 was in strong positive correlation with clinical parameters and all biomarkers except P-gp/ABCB1. The overexpression of MRP1/ABCC1, survivin, and BCRP/ABCC2 presented as high immunoreactive scores (IRSs) was detected in the Refractory and Relapsed groups (p < 0.05 vs. Remission), respectively, whereas the IRS of P-gp/ABCB1 was low. Significant correlations were found among either MRP1/ABCC1 and survivin or BCRP/ABCC2 in the Refractory and Relapsed groups, respectively. In multiple linear regression analysis, ECOG status along with MRP1/ABCC1 or survivin and BRCP/ABCG2 was significantly associated with the prediction of the R-CHOP treatment response. CONCLUSIONS: DLBCL might harbor certain molecular signatures such as MRP1/ABCC1, survivin, and BCRP/ABCC2 overexpression that can predict resistance to R-CHOP.
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Authors | Danijela Mandić, Lana Nežić, Ljiljana Amdžić, Nataša Vojinović, Radoslav Gajanin, Miroslav Popović, Jugoslav Đeri, Milena Todorović Balint, Jelena Dumanović, Zoran Milovanović, Jelica Grujić-Milanović, Ranko Škrbić, Vesna Jaćević |
Journal | Cancers
(Cancers (Basel))
Vol. 15
Issue 16
(Aug 15 2023)
ISSN: 2072-6694 [Print] Switzerland |
PMID | 37627134
(Publication Type: Journal Article)
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