[Advances in enzymatic production of L-homophenylalanine].

Abstract

L-homophenylalanine (L-HPA) is an important non-natural amino acid that has been used as a key intermediate for the synthesis of Puli drugs for the treatment of hypertension. At present, L-HPA is synthesized using chemical methods, which has the disadvantages of expensive raw materials, tedious steps and serious pollution. Therefore, researchers have conducted in-depth research on the enzymatic production of L-HPA. This review summarizes the research progress on the enzymatic synthesis of L-HPA, including the dehydrogenase process, the transaminase process, the hydantoinase process, and the decarboxylase process, with the hope to facilitate the industrial production of L-HPA.

• Authors: Dengke Gao, Wei Song, Wanqing Wei, Kangping Huang, Jing Wu, Liming Liu
• Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology (Sheng Wu Gong Cheng Xue Bao) Vol. 39 Issue 8 Pg. 3111-3124 (Aug 25 2023) ISSN: 1872-2075 [Electronic] China
• PMID: 37622351 (Publication Type: Review, English Abstract, Journal Article)

Chemical References

• 2-amino-4-phenylbutyric acid
• Amino Acids

Topics

• Amino Acids
• Environmental Pollution
• Industry
• Protein Biosynthesis