Abstract | BACKGROUND:
Acne scars cause significant psychosocial stress. Despite a wide armamentarium, there is a constant search for an effective modality. Autologous injectable platelet-rich fibrin (i-PRF) is a promising novel option in the management of atrophic scars. OBJECTIVE: MATERIALS AND METHODS: A split-face prospective interventional study was conducted on 40 patients with atrophic acne scars. Autologous i-PRF and normal saline were injected into each scar on right (study) and left (control) sides, respectively, followed by microneedling on both sides. Four sessions were performed at monthly intervals with follow-up at 2 months. For assessment, Goodman and Baron (GB) scale, physician subjective score, and patient satisfaction scores were used. RESULTS: Mean baseline GB grade on each side was 3.45. At 24 weeks, mean GB grade was significantly reduced on the study side (1.47, SD 0.56) than control side (3.33, SD 0.53). Mean patient satisfaction score was significantly higher on the right side (5.95) compared with the left side (5.35). Rolling scars responded the best followed by boxcar and ice-pick scars. CONCLUSION:
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Authors | Ranjitha Krishnegowda, Shekhar N Pradhan, Vasudha A Belgaumkar |
Journal | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
(Dermatol Surg)
Vol. 49
Issue 10
Pg. 938-942
(10 01 2023)
ISSN: 1524-4725 [Electronic] United States |
PMID | 37584506
(Publication Type: Clinical Trial, Journal Article)
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Copyright | Copyright © 2023 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved. |
Chemical References |
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Topics |
- Humans
- Acne Vulgaris
(complications, therapy)
- Atrophy
(complications)
- Cicatrix
(etiology, therapy, pathology)
- Connective Tissue Diseases
(complications)
- Cosmetic Techniques
(adverse effects)
- Needles
(adverse effects)
- Platelet-Rich Fibrin
- Platelet-Rich Plasma
- Prospective Studies
- Saline Solution
- Treatment Outcome
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