[Comparative experimental study of cyclacillin and ampicillin].

Abstract

Cyclacillin was compared with ampicillin by its bacteriostatic efficiency in vitro, chemotherapeutic efficiency in experimental infections of mice and rats and pharmacokinetic characteristics. It was found that cyclacillin was not superior to ampicillin by its antibacterial action. By a number of characteristics it was even significantly inferior. The pharmacokinetic advantages of cyclacillin were not considered significant.

• Authors: E A Rudzit, V P Iakovlev, T A Zinchenko, D A Kulikova, L I Lisitsa
• Journal: Antibiotiki (Antibiotiki) Vol. 24 Issue 5 Pg. 331-6 (May 1979) ISSN: 0003-5637 [Print] Russia (Federation)
• Vernacular Title: Sravnitel'noe izuchenie tsiklatsillina i ampitsillina v éksperimente.
• PMID: 375825 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Penicillins
• Cyclacillin
• Ampicillin

Topics

• Ampicillin (administration & dosage, blood, therapeutic use)
• Animals
• Cyclacillin (administration & dosage, blood, therapeutic use)
• Drug Evaluation, Preclinical
• Escherichia coli Infections (drug therapy)
• Female
• Kinetics
• Male
• Mice
• Penicillins (therapeutic use)
• Pyelonephritis (drug therapy)
• Rats
• Staphylococcal Infections (drug therapy)
• Time Factors