Asthma is a chronic inflammatory disease of the pulmonary system associated with many wheeze-to-
sleep apnea complications that may lead to death. In 2019, approximately 262 million patients suffered from
asthma, and 455 thousand died from the disease worldwide. It is a more severe health problem in children and older adults, and as the aging of society intensifies, the problem will continue to worsen.
Asthma inducers can be classified as indoor and outdoor
allergens and can cause
asthma due to their repeated invasion. There are several theories about
asthma occurrence, such as the imbalance between Th1 and Th2,
inflammation in the pulmonary system, and the abnormal apoptosis/cell proliferation of cells related to
asthma. Although there are many medications for
asthma, as it is an incurable disease, the purpose of the drugs is only to suppress the symptoms. The current drugs can be divided into relievers and controllers; however, as they have many adverse effects, such as immune suppression, growth retardation, promotion of
cataracts, hyperactivity, and convulsions, developing new
asthma drugs is necessary. Although natural products can have adverse effects, the development of
asthma drugs from natural products may be beneficial, as some have
anti-asthmatic effects such as immune modulation, anti-
inflammation, and/or apoptosis modulation.