Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: Chi006Eese herbal medicine Weifuchun Tablets (WFC) approved by the State Food and Drug Administration in 1982 has been widely used in treating a variety of chronic stomach disorders including Chronic atrophic gastritis (CAG) and Gastric precancerous lesions in China clinically. This study aimed to investigate the efficacy and potential mechanism of WFC in treating Gastric intestinal metaplasia (GIM) and Gastric dysplasia (GDys). MATERIALS AND METHODS: RESULTS: WFC improved rat body weight, histopathology, pH value of gastric acid, activity of gastric pepsin, intestinal metaplasia (CDX2), inflammation (IL-1β, IL-6 and TNF-α), macrophage aggregation (CD68) in gastric mucosa in rat GIM and GDys. WFC inhibited inflammation (IL-1β and TNF-α) by inactivating the NF-κB pathway. WFC reduced the expression of CDX2 by inhibiting the binding of CDX2 promoter TSS upstream region with p65. CONCLUSION: WFC blocked GIM and GDys associated with inflammation by regulating the NF-κB pathway.
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Authors | Dong Xie, Chao Wu, Dan Wang, Bahaji Azami Nisma Lena, Ningning Liu, Guan Ye, Mingyu Sun |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 318
Issue Pt B
Pg. 117020
(Jan 10 2024)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 37567428
(Publication Type: Journal Article)
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Copyright | Copyright © 2023. Published by Elsevier B.V. |
Chemical References |
- NF-kappa B
- Tumor Necrosis Factor-alpha
- Methylnitronitrosoguanidine
- Pepsin A
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Topics |
- Rats
- Animals
- NF-kappa B
(metabolism)
- Tumor Necrosis Factor-alpha
(metabolism)
- Methylnitronitrosoguanidine
- Pepsin A
(metabolism)
- Inflammation
(pathology)
- Precancerous Conditions
(drug therapy)
- Hyperplasia
(pathology)
- Stomach Neoplasms
(pathology)
- Metaplasia
(metabolism, pathology)
- Gastric Mucosa
(pathology)
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