Lactobacillus oris improves non-alcoholic fatty liver in mice and inhibits endogenous cholesterol biosynthesis.

Abstract

We previously confirmed that a strain of Lactobacillus oris isolated from the fecal samples of healthy Hainan centenarian having potent lipid-lowering ability in HepG2 cells; and this study was to investigate the effect of the stain on non-alcoholic fatty liver in mice in vivio. The Lactobacillus oris strain isolated from Hainan centenarian fecal samples were frozen stored in our laboratory. Thirty ob/ob mice (10 in each group) were orally gavaged with Lactobacillus oris (Lactobacillus, 5 × 109 cfu), mixed probiotics (Mixed, 5 × 109 cfu, a mixture with known lipid-lowering ability), or culture medium (Control) respectively. Lactobacillus oris isolated from fecal samples of Hainan centenarians showed significantly in vivo lipid lowering ability compared with the controls, and the ability was comparable with mixed probiotics strains in mice The possible mechanisms of lipid-lowering of probiotics and Lactobacillus oris may be associated with HMGR inhibition to suppress the synthesis of endogenous cholesterol; bile acids reabsorption, and intestinal FXR-FGF15 signaling pathways promoting the cholesterol conversion into bile acids secretion.

• Authors: Yiming Zhao, Congyong Li, Zhe Luan, Jun Chen, Cong Wang, Yujia Jing, Shirui Qi, Zhizhuang Zhao, Hanwen Zhang, Junling Wu, Yi Chen, Zhuanyu Li, Bowen Zhao, Shufang Wang, Yunsheng Yang, Gang Sun
• Journal: Scientific reports (Sci Rep) Vol. 13 Issue 1 Pg. 12946 (08 09 2023) ISSN: 2045-2322 [Electronic] England
• PMID: 37558739 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2023. Springer Nature Limited.

Chemical References

• Cholesterol
• Bile Acids and Salts

Topics

• Mice
• Animals
• Liver (metabolism)
• Lactobacillus (metabolism)
• Non-alcoholic Fatty Liver Disease (therapy, metabolism)
• Cholesterol (metabolism)
• Probiotics (pharmacology)
• Bile Acids and Salts (metabolism)