IgG index of cerebrospinal fluid can reflect pathophysiology associated with Lewy bodies in Parkinson's disease.

Abstract

BACKGROUND:

Neuroinflammation is one of the pathophysiologies of Parkinson's disease (PD). Lewy bodies, the pathological hallmark of PD, emerge as a consequence of α-synuclein aggregation, and neuroinflammation is induced concurrently with this aggregation. Imaging and cerebrospinal fluid (CSF) biomarkers that reflect PD pathophysiology have been developed or are under investigation. The IgG index of CSF is a marker of inflammation, and may also reflect the pathophysiology of PD.

AIM:

We examined if the IgG index reflects the pathophysiology of PD in drug-naïve PD patients.

METHOD:

The subjects were 20 consecutive PD patients who underwent 123I-MIBG scintigraphy for assessment of the heart to mediastinum (H/M) ratio and wash out rate, 123I-Ioflupane SPECT for examination of the specific binding ratio in the striatum, and lumbar puncture before treatment. The CSF IgG index and levels of pathogenic proteins (total α-synuclein, oligomeric α-synuclein, total tau, phosphorylated tau and amyloid Aβ1-42) were determined. The IgG index was compared with the other parameters using Spearman correlation analysis.

RESULTS:

The IgG index showed a significant correlation with the H/M ratio in early (r = -0.563, p = 0.010) and delayed (r = -0.466, p = 0.038) images in 123I-MIBG scintigraphy and with the CSF total tau level (r = -0.513, p = 0.021).

CONCLUSION:

Neuroinflammation is involved in PD pathophysiology in some patients, and a higher IgG index indicates the presence of neuroinflammation accompanied by emergence of Lewy bodies.

• Authors: Hidetomo Murakami, Takahiko Tokuda, Omar M A El-Agnaf, Takuma Ohmichi, Yukiko Mori, Miki Asano, Mizuki Kanemoto, Yasuhiko Baba, Tamao Tsukie, Takeshi Ikeuchi, Kenjiro Ono
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 452 Pg. 120760 (09 15 2023) ISSN: 1878-5883 [Electronic] Netherlands
• PMID: 37544209 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2023. Published by Elsevier B.V.

Chemical References

• alpha-Synuclein
• Iodine-123
• 3-Iodobenzylguanidine
• tau Proteins
• Amyloid beta-Peptides
• Biomarkers
• Immunoglobulin G
• Peptide Fragments

Topics

• Humans
• Parkinson Disease (diagnosis)
• alpha-Synuclein (cerebrospinal fluid)
• Lewy Bodies
• 3-Iodobenzylguanidine
• Neuroinflammatory Diseases
• tau Proteins (cerebrospinal fluid)
• Amyloid beta-Peptides (cerebrospinal fluid)
• Biomarkers (cerebrospinal fluid)
• Immunoglobulin G
• Peptide Fragments (cerebrospinal fluid)