Ofatumumab and Early Immunological Cells Subset Characterization in Naïve Relapsing Multiple Sclerosis Patients: A Real-World Study.

Abstract

BACKGROUND:

Ofatumumab (OFA) is a fully human anti-CD20 monoclonal antibody administered with a 20 mg subcutaneous monthly dosing regimen.

METHODS:

Inclusion criteria were patients: 1) aged 18-55; 2) with a confirmed diagnosis of relapsing Multiple Sclerosis (RMS), per the revised 2010 McDonald criteria; 2) who started OFA according to Italian Medicines Agency prescription rules and within 12 months from the RMS diagnosis; 3) naïve to any disease-modifying therapy. The primary outcome was to offer an overview of cellular subsets of RMS naïve patients (time 0) and then after 4 weeks (time 1) and 12 weeks (time 2) on therapy with OFA in a real-world setting.

RESULTS:

Fifteen patients were enrolled. CD3+ T cell frequencies were higher at time 1 (%80.4, SD 7.7) and time 2 (%82.6, SD 5.8) when compared to time 0 (%72.4, SD 9.8), p = .013. B naïve cells were barely detectable in the OFA group at time 1 (%0.4, SD 0.5) and 2 (%1.4, SD 2.9) when compared to time 0 (%11.5, SD 3.8), p < .001.

CONCLUSION:

The progressive and increasing use of anti-CD20 drugs imposes the need for larger, prospective, real-world, long-term studies to characterize further immunophenotypes of patients with RMS treated with OFA.

• Authors: Emanuele D'Amico, Aurora Zanghì, Roberta Fantozzi, Diego Centonze, Carlo Avolio
• Journal: Current neuropharmacology (Curr Neuropharmacol) Vol. 21 Issue 12 Pg. 2563-2566 ( 2023) ISSN: 1875-6190 [Electronic] United Arab Emirates
• PMID: 37534789 (Publication Type: Journal Article)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• ofatumumab
• Antibodies, Monoclonal, Humanized
• Antibodies, Monoclonal

Topics

• Humans
• Multiple Sclerosis (drug therapy)
• Prospective Studies
• Antibodies, Monoclonal, Humanized (therapeutic use)
• Antibodies, Monoclonal (adverse effects)