In India,
breast cancer is the most common cause of mortality for women and has the potential to spread to other body organs. As a
transcription factor, interactions with the
estrogen receptor (ER) alpha are primarily responsible for the development of malignant
tumors.
Aromatase inhibitors are the most often used treatment for ER(+)
breast cancer. Various synthetic compounds have been developed over the years to block the
aromatase receptor, however, the majority of them are hazardous and cause multidrug resistance. So, combating these natural drugs can be prioritized. The current study was conducted to investigate the anticancer potential of Lagenaria siceraria phytoconstituents against
breast cancer target
protein (PDB ID: 3EQM) based on a literature review. In this study, 34 Lagenaria siceraria
ligands were chosen, and the structure of the human
aromatase receptor was acquired from the
protein data bank. For those natural chemicals, molecular docking,
drug-likeness, toxicity, and molecular dynamics were used to evaluate and analyse their anti-
breast cancer activity. Five substances, 2,3-Diphenyl
quinoxaline, 17-Acetoxy pregnolone, Benzyl-d-
glucoside, Ergostenol
acetate, and
Stigmast-7-en-3-ol, shown higher binding affinity than
Tamoxifen, signaling their potential use in
breast cancer treatment.