Serpin family A member 1 (SERPINA1) encodes a
protease inhibitor participating in many human diseases, but its value in immunoregulation and prognosis of human
cancers remains unclear. In this study, through comprehensive analysis of data from The
Cancer Genome Atlas (TCGA) datasets, we found that SERPINA1 was dysregulated in many
cancers compared with normal tissues. SERPINA1 expression was significantly associated with prognosis, immune subtype, molecular subtype, immune checkpoint (ICP) genes,
tumor mutational burden (TMB),
microsatellite instability (MSI), and the estimation of stromal and immune cells in malignant
tumor tissues using expression data (ESTIMATE) score. There was a strong connection between SERPINA1 expression and tumor-infiltrating lymphocytes, and SERPINA1 showed significant relation to gene markers of immune cells in digestive
tumors. Fluorescence-based multiplex immunohistochemistry confirmed that SERPINA1
protein expression was related to clinicopathologic features and immune infiltrates in
hepatic cancer. This study suggests that SERPINA can potentially serve as a novel
biomarker for
cancer prognosis and
immunotherapy.