Analysis of lncRNAs profiles associated with ferroptosis can predict prognosis and immune landscape and drug sensitivity in patients with clear cell renal cell carcinoma.

Abstract

Ferroptosis is a novel kind of iron- and reactive oxygen-induced cell death, investigation into ferroptosis-associated long noncoding RNAs (FALs) in clear cell renal cell carcinoma (ccRCC) is scarce. The goal of the research was to look at FALs' possible predictive significance, as well as their interaction with the immune microenvironment and therapeutic responsiveness of ccRCC. The Cancer Genome Atlas database was employed to retrieve RNA sequencing data from 530 individuals with ccRCC. Patients with ccRCC were randomly assigned to one of two groups: training or testing. Pearson's correlation analysis through the identified ferroptosis-related genes was implemented to screen for FALs. Finally, a FALs signature composed of eight lncRNAs was discovered for predicting survival outcomes in ccRCC patients. ccRCC patients in the training, testing, and overall cohorts were separated into low-risk and high-risk groups based on their risk score. The FALs signature was identified to be an independent factor for overall survival in the multivariate Cox analysis (hazard ratio = 1.013, 95% confidence interval = 1.008-1.018, p < 0.001). A clinically prognostic nomogram was created depending on the FALs signature and clinical characteristics. The nomogram provides greater clinical practicability and may reliably estimate patients' overall survival. The FALs signature may additionally precisely represent ccRCC's immunological environment, immunotherapy reaction, and drug sensitivity. The eight FALs and their signature provide precise and reliable methods for evaluating the clinical effects of in ccRCC patients, and they could be biological markers and targets for therapy.

• Authors: Huantao Zong, Anning Li, Yongjin Huang, Xuanyan Che, Yong Zhang, Guikai Ma, Zhongbao Zhou
• Journal: Journal of biochemical and molecular toxicology (J Biochem Mol Toxicol) Vol. 37 Issue 11 Pg. e23464 (Nov 2023) ISSN: 1099-0461 [Electronic] United States
• PMID: 37477388 (Publication Type: Randomized Controlled Trial, Journal Article)
• Copyright: © 2023 Wiley Periodicals LLC.

Chemical References

• RNA, Long Noncoding

Topics

• Humans
• Carcinoma, Renal Cell (drug therapy, genetics)
• RNA, Long Noncoding (genetics)
• Ferroptosis (genetics)
• Carcinoma
• Kidney Neoplasms (genetics)
• Tumor Microenvironment (genetics)