Mesoporous
silica nanoparticles (MSN) have attracted widespread attention in the field of drug delivery and biomedicine due to their unique structure and physicochemical properties. However, MSN still have shortcomings, such as premature drug release, poorly controlled release ability and poor targeting. Therefore, in order to reduce the damage of anti-
cancer drugs to normal cells, improve their utilization rate and realize their selective release in
tumor cells, "gated" stimuli-responsive mesoporous
silicon nanomaterials as
antitumor drug delivery carriers have attracted widespread interest among researchers. The "gated" stimuli-responsive nanovalves drug delivery system can only be removed under certain specific stimuli, which makes the drug maintain "zero release" before reaching the lesion site and achieve drug accumulation in
tumor cells, effectively reducing the toxic and side effects on normal cells or tissues, and greatly exerting the efficacy of anti-
cancer drugs. Therefore, the construction of stimuli-responsive
nano-drug delivery systems have great application potential and significance in
cancer treatment and controlled release of anti-
cancer drugs. This review article emphasizes the research progress of the "gated" stimuli-responsive MSN (e.g. pH, redox potential,
enzyme, temperature and light) or controlled drug release and
cancer treatment since 2019.