Objective: To evaluate the efficacy of CT-guided partial
radiofrequency ablation of bilateral responsible cranial nerves in the treatment of
Meige syndrome. Methods: The Clinical data of 56 patients with
Meige syndrome in the Department of
Pain Medicine, Affiliated Hospital of Jiaxing University from June 2019 to January 2023 were retrospectively analyzed [19 males and 37 females, aged 42-76 (58.6±8.3) years], including 51 cases of
blepharospasm, 3 cases of oromandibular
dystonia and 2 cases of
blepharospasm concomitant with oromandibular
dystonia. CT-guided partial
radiofrequency ablation of bilateral responsible cranial nerves was performed on different types of
Meige syndrome. And the efficacy and complications of the technique were observed. Results: Fifty-one patients with
blepharospasm Meige syndrome underwent CT-guided radiofrequency of facial nerve through bilateral stylomastoid foramen
punctures, the symptoms of
blepharospasm disappeared completely, leaving bilateral mild and moderate
facial paralysis symptoms. Three patients with oral-mandibular
dystonia underwent CT-guided
radiofrequency therapy by bilateral foramen ovale
puncture of mandibular branches of trigeminal nerve, masticatory muscle
spasm disappeared, the patients had no difficulty opening the mouth, and the skin
numbness in bilateral mandibular nerve innervation area was left. Two cases of
Meige syndrome with
blepharospasm concomitant with oromandibular
dystonia were treated by radiofrequency of facial nerve and mandibular branch of trigeminal nerve, and all symptoms disappeared. The patients were followed up for 1-44 months after the operation, and the symptoms of mild and moderate
facial paralysis disappeared at (3.2±0.8) months after the operation, but the
numbness did not disappear. Three patients with
blepharospasm recurred at the 14, 18 and 22 months after the operation, respectively, while the rest cases did not recur. Conclusions: According to different types of
Meige syndrome, CT-guided partial
radiofrequency ablation of responsible cranial nerves can effectively treat the corresponding type of
Meige syndrome. The complications are only mild and moderate
facial paralysis which can be recovered, and/or skin
numbness in the mandibular region.