Outcomes of treatment of cats with feline infectious peritonitis using parenterally administered remdesivir, with or without transition to orally administered GS-441524.

Abstract

BACKGROUND:

Nucleoside analog GS-441524 is effective in treating cats with feline infectious peritonitis (FIP). Investigation into the use of parent nucleotide analog remdesivir (GS-5734) is needed.

OBJECTIVES:

To assess efficacy and tolerability of remdesivir with or without transition to GS-441524 in cats with FIP and document clinical and clinicopathologic progression over 6 months.

ANIMALS:

Twenty-eight client-owned cats with FIP.

METHODS:

Cats were prospectively recruited between May 2021 and May 2022. An induction dosage of remdesivir 10 to 15 mg/kg intravenously or subcutaneously q24h was utilized for 4 doses, with a maintenance dosage of remdesivir (6-15 mg/kg SC) or GS-441524 (10-15 mg/kg per os) every 24 hours continued for at least 84 days. Laboratory testing, veterinary, and owner assessments were recorded.

RESULTS:

Twenty-four cats survived to 6 months (86%). Three cats died within 48 hours. Excluding these, survival from 48 hours to 6 months was 96% (24/25). Remission was achieved by day 84 in 56% (14/25). Three cats required secondary treatment for re-emergent FIP. Remission was achieved in all 3 after higher dosing (15-20 mg/kg). Adverse reactions were occasional site discomfort and skin irritation with remdesivir injection. Markers of treatment success included resolution of pyrexia, effusions, and presenting signs of FIP in the first half of treatment and normalization of globulin concentration, and continued body weight gains in the latter half of the treatment period.

CONCLUSIONS AND CLINICAL IMPORTANCE:

Parenteral administration of remdesivir and oral administration of GS-441524 are effective and well-tolerated treatments for FIP. Early emphasis on clinical, and later emphasis on clinicopathologic response, appears prudent when monitoring treatment efficacy.

• Authors: Sally J Coggins, Jacqui M Norris, Richard Malik, Merran Govendir, Evelyn J Hall, Benjamin Kimble, Mary F Thompson
• Journal: Journal of veterinary internal medicine (J Vet Intern Med) 2023 Sep-Oct Vol. 37 Issue 5 Pg. 1772-1783 ISSN: 1939-1676 [Electronic] United States
• PMID: 37439383 (Publication Type: Journal Article)
• Copyright: © 2023 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.

Chemical References

• remdesivir
• GS-441524

Topics

• Humans
• Cats
• Animals
• Feline Infectious Peritonitis (drug therapy)
• Exudates and Transudates
• Coronavirus, Feline
• Cat Diseases (drug therapy)