[Dermatomyositis].

Abstract

Dermatomyositis is a heterogeneous disorder that can be classified into more homogeneous subsets. Autoantibodies are a useful tool in identifying such subsets because they correlate strongly with clinical phenotypes. In dermatomyositis, five disease-specific autoantibodies have been established to date, including antiMi-2, anti-melanoma differentiation-associated gene 5, anti-transcriptional intermediary factor 1, anti-nuclear matrix protein 2, anti-transcriptional intermediary factor 1, and anti-small-ubiquitin-like activating enzyme antibodies. In addition, several novel autoantibodies have recently been demonstrated in patients with dermatomyositis, including anti-four-and-a-half-LIM-domain 1, anti-cell division cycle and apoptosis regulator protein 1, anti-specificity protein 4, anti-cortactin, and IgM anti-angiotensin converting enzyme 2 antibodies.

• Authors: Manabu Fujimoto
• Journal: Brain and nerve = Shinkei kenkyu no shinpo (Brain Nerve) Vol. 75 Issue 7 Pg. 847-854 (Jul 2023) ISSN: 1881-6096 [Print] Japan
• PMID: 37431075 (Publication Type: English Abstract, Journal Article)

Chemical References

• Autoantibodies
• Ubiquitin-Activating Enzymes

Topics

• Humans
• Dermatomyositis (diagnosis)
• Autoantibodies
• Ubiquitin-Activating Enzymes