Zaltoprofen, a unique
propionic acid group of
NSAIDs, works by blocking the enhancing effects of
bradykinin along with the COX-2
enzyme. Therefore, it is of interest to evaluate the acute and chronic anti-inflammatory (arthritic) potential of
zaltoprofen versus
piroxicam in Murine models. A total of 48 Wister rats (200-250 g) of either sex (24 in each model) were used in the present study. The anti-inflammatory and arthritic potential of
zaltoprofen was evaluated and compared by
Carrageenan-induced acute
inflammation and
formalin-induced chronic
inflammation. There was a significant inhibition of paw volume (P<0.001) on different time scales with two different doses of the test compound (
Zaltoprofen 10 & 20 mg/kg) in the acute
inflammation model compared to the negative control (NaCl 10 ml/kg). However, in the chronic
inflammation model,
zaltoprofen 10 mg/kg and 20 mg/kg doses of the test compound showed a significant reduction in chronic
inflammation, comparable to the negative control (NaCl 10 ml/kg), although the potency was lower than the positive control (
piroxicam 10 mg/kg) (P 0.05). Thus,
zaltoprofen shows significant anti-inflammatory and arthritic effects in both acute and chronic models by inhibiting various inflammatory mediators.