Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism.

Abstract

MDL 72222, the selective 5-hydroxytryptamine (5-HT) M-receptor antagonist, prevented or reduced cisplatin-induced emesis in ferrets. It is suggested that cisplatin-induced, and possibly other cytotoxic drug-induced vomiting may involve a 5-HT M-receptor mechanism.

• Authors: W D Miner, G J Sanger
• Journal: British journal of pharmacology (Br J Pharmacol) Vol. 88 Issue 3 Pg. 497-9 (Jul 1986) ISSN: 0007-1188 [Print] England
• PMID: 3742146 (Publication Type: Journal Article)

Chemical References

• Receptors, Serotonin
• Serotonin Antagonists
• Tropanes
• bemesetron
• Cisplatin

Topics

• Animals
• Cisplatin (antagonists & inhibitors, toxicity)
• Ferrets
• Male
• Receptors, Serotonin (drug effects)
• Serotonin Antagonists (pharmacology)
• Tropanes (pharmacology)
• Vomiting (chemically induced, prevention & control)