[Efficacy of fesoterodine for prevention of autonomic dysreflexia in patients with neurogenic dysfunction of the bladder after spinal cord injury].

Abstract

AIM:

to evaluate the effectiveness of fesoterodine for the prevention of autonomic dysreflexia (AD) in patients with neurogenic bladder dysfunction (NBD) after spinal cord injury (SCI).

MATERIALS AND METHODS:

a total of 53 patients with AD were included in the study. In the main group (n=33) patients received fesoterodine 4 mg per day for 12 weeks as a treatment for neurogenic bladder dysfunction and prevention of AD. In the control group (n=20), patients were monitored for 12 weeks without specific treatment. The assessment was based on the results of ADFSCI and NBSS questionnaires, daily blood pressure monitoring with the completion of a self-observation diary, cystometry with simultaneous monitoring of blood pressure and heart rate.

RESULTS:

In the main group there was a significant decrease in episodes and severity of AD according to ADFSCI questionnaire and an improvement in the quality of life according to NBSS questionnaire compared to the control group (p<0.001). Also, in the main group, the number of episodes of AD and systolic blood pressure decreased. The maximum bladder capacity and bladder compliance increased (p<0.001), and the maximum detrusor pressure and systolic blood pressure when the cystometric capacity was reached, decreased significantly (p<0.001) in the main group compared in comparison with the control group.

CONCLUSION:

Fesoterodine at a dosage of 4 mg for 12 weeks reduced the severity of symptoms of AD in patients with SCI and NBD, which was manifested by the stabilization of blood pressure and a decrease in the number of episodes of AD, which significantly improved the quality of life. Also, the drug led to a significant improvement in urodynamic parameters during cystometry, in the form of a decrease in detrusor pressure and an increase in cystometric capacity. We can conclude that fesoterodine is effective in the prevention of AD in patients with NBD after SCI.

• Authors: R V Salyukov, A A Kamalov, D A Okhobotov, M E Chalyi, M V Frolova
• Journal: Urologiia (Moscow, Russia : 1999) (Urologiia) Issue 3 Pg. 47-51 (Jul 2023) ISSN: 1728-2985 [Print] Russia (Federation)
• PMID: 37417411 (Publication Type: English Abstract, Journal Article)

Chemical References

• fesoterodine

Topics

• Humans
• Autonomic Dysreflexia (drug therapy, etiology, prevention & control)
• Urinary Bladder
• Urinary Bladder, Neurogenic (drug therapy, etiology)
• Quality of Life
• Spinal Cord Injuries (complications, drug therapy)
• Urodynamics (physiology)