Icenticaftor, a CFTR Potentiator, in COPD: A Multicenter, Parallel-Group, Double-Blind Clinical Trial.

Abstract

Rationale: CFTR (cystic fibrosis transmembrane conductance regulator) dysfunction is associated with mucus accumulation and worsening chronic obstructive pulmonary disease (COPD) symptoms. Objectives: The aim of this phase IIb dose-finding study was to compare a CFTR potentiator, icenticaftor (QBW251), with placebo in patients with COPD and chronic bronchitis. Methods: Patients with COPD on triple therapy for at least three months were randomized to six treatment arms (icenticaftor 450, 300, 150, 75, or 25 mg or placebo twice daily [b.i.d.]) in a 24-week, multicenter, parallel-group, double-blind study. The primary endpoint was change from baseline in trough FEV1 after 12 weeks. Secondary endpoints included change from baseline in trough FEV1 and Evaluating Respiratory Symptoms in COPD (E-RS) total and cough and sputum scores after 24 weeks. Multiple comparison procedure-modeling was conducted to characterize dose-response relationship. Rescue medication use, exacerbations, and change in serum fibrinogen concentration after 24 weeks were assessed in exploratory and post hoc analyses, respectively. Measurements and Main Results: Nine hundred seventy-four patients were randomized. After 12 weeks of icenticaftor treatment, no dose-response relationship for change from baseline in trough FEV1 was observed; however, it was observed for E-RS cough and sputum score. A dose-response relationship was observed after 24 weeks for trough FEV1, E-RS cough and sputum and total scores, rescue medication use, and fibrinogen. A dose of 300 mg b.i.d. was consistently the most effective. Improvements for 300 mg b.i.d. versus placebo were also seen in pairwise comparisons of these endpoints. All treatments were well tolerated. Conclusions: The primary endpoint was negative, as icenticaftor did not improve trough FEV1 over 12 weeks. Although the findings must be interpreted with caution, icenticaftor improved trough FEV1; reduced cough, sputum, and rescue medication use; and lowered fibrinogen concentrations at 24 weeks. Clinical trial registered with www.clinicaltrials.gov (NCT04072887).

• Authors: Fernando J Martinez, Gerard J Criner, Christian Gessner, Margret Jandl, Fernando Scherbovsky, Masaharu Shinkai, Thomas M Siler, Claus F Vogelmeier, Robert Voves, Jadwiga A Wedzicha, Christian Bartels, Ivan Bottoli, Stuart Byiers, Pamela Cardenas, Joerg H Eckert, Florian S Gutzwiller, Barbara Knorr, Mahavir Kothari, Rutvick Parlikar, Ana-Maria Tanase, Frits M E Franssen
• Journal: American journal of respiratory and critical care medicine (Am J Respir Crit Care Med) Vol. 208 Issue 4 Pg. 417-427 (08 15 2023) ISSN: 1535-4970 [Electronic] United States
• PMID: 37411039 (Publication Type: Randomized Controlled Trial, Multicenter Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• icenticaftor
• Cystic Fibrosis Transmembrane Conductance Regulator
• CFTR protein, human

Topics

• Humans
• Cystic Fibrosis Transmembrane Conductance Regulator (genetics)
• Cough (drug therapy, complications)
• Pulmonary Disease, Chronic Obstructive
• Bronchitis, Chronic
• Double-Blind Method
• Forced Expiratory Volume
• Treatment Outcome