Abstract |
The polysaccharides from Auricularia auricula (AAPs), containing a large number of O-acetyl groups that are related to the physiological and biological properties, seem to be potential prebiotics like other edible fungus polysaccharides. In the present study, therefore, the alleviating effects of AAPs and deacetylated AAPs (DAAPs, prepared from AAPs by alkaline treatment) on nonalcoholic fatty liver disease ( NAFLD) induced by high-fat and high- cholesterol diet combined with carbon tetrachloride were investigated. The results revealed that both AAPs and DAAPs could effectively relieve liver injury, inflammation and fibrosis, and maintain intestinal barrier function. Both AAPs and DAAPs could modulate the disorder of gut microbiota and altered the composition of gut microbiota with enrichment of Odoribacter, Lactobacillus, Dorea and Bifidobacterium. Further, the alteration of gut microbiota, especially enhancement of Lactobacillus and Bifidobacterium, was contributed to the changes of bile acids (BAs) profile with increased deoxycholic acid (DCA). Farnesoid X receptor could be activated by DCA and other unconjugated BAs, which participated the BAs metabolism and alleviated the cholestasis, then protected against hepatitis in NAFLD mice. Interestingly, it was found that the deacetylation of AAPs negatively affected the anti- inflammation, thereby reducing the health benefits of A. auricula-derived polysaccharides.
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Authors | Yifan Shu, Yujie Huang, Wei Dong, Xia Fan, Yi Sun, Guijie Chen, Xiaoxiong Zeng, Hong Ye |
Journal | International journal of biological macromolecules
(Int J Biol Macromol)
Vol. 246
Pg. 125662
(Aug 15 2023)
ISSN: 1879-0003 [Electronic] Netherlands |
PMID | 37399869
(Publication Type: Journal Article)
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Copyright | Copyright © 2023 Elsevier B.V. All rights reserved. |
Chemical References |
- Polysaccharides
- Bile Acids and Salts
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Topics |
- Mice
- Animals
- Non-alcoholic Fatty Liver Disease
(metabolism)
- Gastrointestinal Microbiome
- Liver
(metabolism)
- Polysaccharides
(pharmacology, therapeutic use, metabolism)
- Bile Acids and Salts
(metabolism)
- Mice, Inbred C57BL
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