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Hypoferremia of inflammation: Innate host defense against infections.

Abstract
Iron is an essential nutrient for microbes, plants and animals. Multicellular organisms have evolved multiple strategies to control invading microbes by restricting microbial access to iron. Hypoferremia of inflammation is a rapidly-acting organismal response that prevents the formation of iron species that would be readily accessible to microbes. This review takes an evolutionary perspective to explore the mechanisms and host defense function of hypoferremia of inflammation and its clinical implications.
AuthorsTomas Ganz, Elizabeta Nemeth
JournalBlood cells, molecules & diseases (Blood Cells Mol Dis) Vol. 104 Pg. 102777 (01 2024) ISSN: 1096-0961 [Electronic] United States
PMID37391347 (Publication Type: Review, Journal Article)
CopyrightCopyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Hepcidins
  • Iron
Topics
  • Animals
  • Hepcidins
  • Inflammation
  • Iron

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