Vitamin E in the management of pancreatic cancer: A scoping review.

Abstract

Pancreatic cancer is the leading cause of cancer mortality worldwide. Research investigating effective management strategies for pancreatic cancer is ongoing. Vitamin E, consisting of both tocopherol and tocotrienol, has demonstrated debatable effects on pancreatic cancer cells. Therefore, this scoping review aims to summarize the effects of vitamin E on pancreatic cancer. In October 2022, a literature search was conducted using PubMed and Scopus since their inception. Original studies on the effects of vitamin E on pancreatic cancer, including cell cultures, animal models and human clinical trials, were considered for this review. The literature search found 75 articles on this topic, but only 24 articles met the inclusion criteria. The available evidence showed that vitamin E modulated proliferation, cell death, angiogenesis, metastasis and inflammation in pancreatic cancer cells. However, the safety and bioavailability concerns remain to be answered with more extensive preclinical and clinical studies. More in-depth analysis is necessary to investigate further the role of vitamin E in the management of pancreatic cancers.

• Authors: Sophia Ogechi Ekeuku, Effiong Paul Etim, Kok-Lun Pang, Kok-Yong Chin, Chun-Wai Mai
• Journal: World journal of gastrointestinal oncology (World J Gastrointest Oncol) Vol. 15 Issue 6 Pg. 943-958 (Jun 15 2023) ISSN: 1948-5204 [Print] China
• PMID: 37389119 (Publication Type: Journal Article, Review)
• Copyright: ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.