Entering, Linked with the Sphinx: Lysophosphatidic Acids Everywhere, All at Once, in the Oral System and Cancer.

Abstract

Oral health is crucial to overall health, and periodontal disease (PDD) is a chronic inflammatory disease. Over the past decade, PDD has been recognized as a significant contributor to systemic inflammation. Here, we relate our seminal work defining the role of lysophosphatidic acid (LPA) and its receptors (LPARs) in the oral system with findings and parallels relevant to cancer. We discuss the largely unexplored fine-tuning potential of LPA species for biological control of complex immune responses and suggest approaches for the areas where we believe more research should be undertaken to advance our understanding of signaling at the level of the cellular microenvironment in biological processes where LPA is a key player so we can better treat diseases such as PDD, cancer, and emerging diseases.

• Authors: D Roselyn Cerutis, Michael D Weston, Takanari Miyamoto
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 24 Issue 12 (Jun 17 2023) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 37373424 (Publication Type: Journal Article, Review)

Chemical References

• Receptors, Lysophosphatidic Acid
• Lysophospholipids

Topics

• Humans
• Receptors, Lysophosphatidic Acid
• Lysophospholipids (physiology)
• Neoplasms
• Signal Transduction
• Inflammation
• Tumor Microenvironment